![Fig. 4. | Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System | Drug Metabolism & Disposition Fig. 4. | Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System | Drug Metabolism & Disposition](https://dmd.aspetjournals.org/content/45/7/855/F4.large.jpg)
Fig. 4. | Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System | Drug Metabolism & Disposition
The pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury | Oncotarget
![Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers | Drug Metabolism & Disposition Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers | Drug Metabolism & Disposition](https://dmd.aspetjournals.org/content/dmd/43/3/309/F8.large.jpg)
Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers | Drug Metabolism & Disposition
![Bioactivation of Diclofenac in Vitro and in Vivo: Correlation to Electrochemical Studies | Chemical Research in Toxicology Bioactivation of Diclofenac in Vitro and in Vivo: Correlation to Electrochemical Studies | Chemical Research in Toxicology](https://pubs.acs.org/cms/10.1021/tx700419d/asset/images/medium/tx-2007-00419d_0001.gif)
Bioactivation of Diclofenac in Vitro and in Vivo: Correlation to Electrochemical Studies | Chemical Research in Toxicology
![Application Data-Metabolism-Diclofenac | Yecuris FRG: Liver-Humanized Mice & Preclinical Research Services Application Data-Metabolism-Diclofenac | Yecuris FRG: Liver-Humanized Mice & Preclinical Research Services](https://www.yecuris.com/wp-content/uploads/2018/04/diclofenac_metabolism.gif)
Application Data-Metabolism-Diclofenac | Yecuris FRG: Liver-Humanized Mice & Preclinical Research Services
![Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters | Molecular Pharmacology Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters | Molecular Pharmacology](https://molpharm.aspetjournals.org/content/molpharm/77/4/687/F1.large.jpg)
Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters | Molecular Pharmacology
![DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES | Drug Metabolism & Disposition DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES | Drug Metabolism & Disposition](https://dmd.aspetjournals.org/content/dmd/33/6/706/F1.large.jpg)
DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES | Drug Metabolism & Disposition
![Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study | Bentham Science Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study | Bentham Science](https://www.eurekaselect.com/images/graphical-abstract/dml/13/1/007.jpg)
Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study | Bentham Science
![PDF] Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile. | Semantic Scholar PDF] Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/399cf5145c115c97ea726b1579f45b48e049ca96/2-Figure1-1.png)
PDF] Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile. | Semantic Scholar
![The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | SpringerLink The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00204-018-2212-1/MediaObjects/204_2018_2212_Fig6_HTML.gif)
The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | SpringerLink
![PDF] Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism. | Semantic Scholar PDF] Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/e57aec319f184f6c34df7de2474a9f7eee518bbb/2-Figure1-1.png)
PDF] Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism. | Semantic Scholar
![The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | SpringerLink The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00204-018-2212-1/MediaObjects/204_2018_2212_Fig5_HTML.gif)
The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | SpringerLink
![Cancers | Free Full-Text | Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases Cancers | Free Full-Text | Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases](https://pub.mdpi-res.com/cancers/cancers-14-04385/article_deploy/html/images/cancers-14-04385-g001.png?1662701546)
Cancers | Free Full-Text | Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
![Metabolic pathway for the generation of the major [ 14 C]-diclofenac... | Download Scientific Diagram Metabolic pathway for the generation of the major [ 14 C]-diclofenac... | Download Scientific Diagram](https://www.researchgate.net/publication/259309957/figure/fig3/AS:392547370324019@1470601994939/Metabolic-pathway-for-the-generation-of-the-major-14-C-diclofenac-metabolites-observed.png)
Metabolic pathway for the generation of the major [ 14 C]-diclofenac... | Download Scientific Diagram
![Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice - ScienceDirect Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1567576920308663-gr1.jpg)
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice - ScienceDirect
![Cytochrome P450 3A4-Mediated Interaction of Diclofenac and Quinidine | Drug Metabolism & Disposition Cytochrome P450 3A4-Mediated Interaction of Diclofenac and Quinidine | Drug Metabolism & Disposition](https://dmd.aspetjournals.org/content/dmd/28/9/1043/F1.large.jpg)